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Single-Cell RNA Sequencing Reveals the Immunological Profiles of Renal Allograft Rejection in Mice.

Frontiers in immunology - 1 Jan 2021

Shen Qixia, Wang Yucheng, Chen Jiaoyi, Ma Lifeng, Huang Xiaoru, Tang Sydney C W, Lan Huiyao, Jiang Hong, Chen Jianghua

Abstract excerpt

Allograft rejection is a common immunological feature in renal transplantation and is associated with reduced graft survival. A mouse renal allograft rejection model was induced and single-cell RNA sequencing (scRNA-seq) data of CD45+ leukocytes in kidney allografts on days 7 (D7) and 15 (D15) after operation was analyzed to reveal a full immunological profiling. We identified 20 immune cell types among 10,921...

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Acute Disease
Cell Communication
Graft Rejection
Kidney Transplantation
Leukocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Single-Cell Analysis

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PMID: 34367152
DOI: 10.3389/fimmu.2021.693608
PMCID: PMC8340022

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