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Single-cell transcriptomic analysis of renal allograft rejection reveals insights into intragraft TCR clonality

25 May 2023

Abstract excerpt

Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding of how rejection occurs despite immunosuppression (IS). We performed combined single-cell RNA transcriptomic and TCR-α/β sequencing on rBx from patients with ACR under differing IS drugs: tacrolimus, iscalimab, and...

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PMID: 37227784
DOI: 10.1172/jci170191

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