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Article

Transplantation: molecular phenotyping of T-cell-mediated rejection.

Nature reviews. Nephrology - 1 Dec 2014

Chong Anita S, Perkins David L

Abstract excerpt

A new study has reported a molecular signature of T-cell-mediated rejection in human kidney transplant biopsy samples that is enriched for effector T cells, interferon-γ and macrophages. Inhibitors of T-cell activation, such as CTLA4 and PDL1, were also prominent, raising the possibility that these immunological constrains could be harnessed by therapies for treating rejection.

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Source

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Identifiers

PMID: 25347945
DOI: 10.1038/nrneph.2014.197
PMCID: PMC4425203

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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