Article

Adaptive Immune Landscape of T-Cell Mediated Rejection of Human Kidney Allografts

2022-05-16

Abstract excerpt

The frequently occurring T cell mediated rejection (TCMR) is a risk factor for allograft failure. Immunosuppressive therapy fails to reverse almost 40% of TCMRs occurring in human kidney allografts. A better understanding of the molecular mechanisms of TCMR and precision therapeutics may improve allograft longevity. We investigated adaptive immune landscape of TCMR by genome wide RNA sequencing of 34 prototypic ki...

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Literature Corpus work: c799d78c-c80f-589f-b5aa-8e99c59d82b5
DOI: 10.1101/2022.05.15.492021

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