Article

Single cell transcriptomic analysis of renal allograft rejection reveals novel insights into intragraft TCR clonality

2023-02-08

Abstract excerpt

Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding. We performed combined single cell RNA transcriptomic and TCRα/β sequencing on rBx from patients with ACR under differing immunosuppression (IS): tacrolimus, iscalimab, and belatacept. TCR analysis revealed a highly r...

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Literature Corpus work: e71fb5a7-c2ab-5804-969d-d42e4d0ab50e
DOI: 10.1101/2023.02.08.524808

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