Article

Ambroxol displaces α-synuclein from the membrane and inhibits the formation of early protein-lipid coaggregates <sup>†</sup>

2025-08-20

Abstract excerpt

Parkinson’s disease (PD) is a neurological disorder characterized by neuronal loss and the deposition of α -synuclein-lipid coaggregates in the brain of patients as well as disruptions in lipid metabolism. Mutations in the gene GBA , which encodes the lysosomal glycoprotein Glucocerebrosidase, are together the most important genetic risk factor for PD and have been associated with lysosomal dysfunction, accumula...

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Literature Corpus work: a7a91d54-9319-5568-97e3-9a5b1d7ea0c2
DOI: 10.1101/2025.08.15.670491

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