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Article

Cholesterol and multilamellar bodies: Lysosomal dysfunction in GBA-Parkinson disease.

Autophagy - 1 Jan 2018

García-Sanz Patricia, Orgaz Lorena, Fuentes José M, Vicario Carlos, Moratalla Rosario

Abstract excerpt

Lipid and cholesterol metabolism might play a role in the pathogenesis of Parkinson disease (PD). However, the association between cholesterol and PD is not clearly established. Cholesterol accumulation is closely related to the expression of multilamellar bodies (MLBs). Also, cholesterol controls autophagosome transport. Thus, impaired cholesterol and autophagosome trafficking might lead to robust autophagic...

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Identifiers

PMID: 29368986
DOI: 10.1080/15548627.2018.1427396
PMCID: PMC5959320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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