Article

Glucocerebrosidase rescues alpha-synuclein from amyloid formation

2018-07-06

Abstract excerpt

Aggregation of the protein α -synuclein ( α Syn) Into amyloid fibrils is associated with Parkinson’s disease (PD), a process accelerated by lipids. Recently, the lysosomal protein glucocerebrosidase (GCase) has been identified as a major risk factor in both genetic and sporadic PD. Here, we use solution state NMR to reveal that GCase directly inhibits lipid induced α Syn amyloidogenesis. Structurally, we show t...

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Literature Corpus work: d33b35e7-586a-53ff-a4aa-6695df3c2122
DOI: 10.1101/363986

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