Article

Comparison of germline and somatic structural variants in cancers reveal systematic differences in variant generating and selection processes

2023-10-12

Abstract excerpt

Although several recent studies have characterized structural variants (SVs) in germline and cancer genomes, the features of SVs in these different contexts have not been directly compared. We examined similarities and differences between 2 million germline and 115 thousand tumor SVs from a cohort of 963 patients from The Cancer Genome Atlas (TCGA). We found significant differences in features related to their gen...

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Literature Corpus work: a7a059ad-251d-5d1d-96d9-fc88827ae5f4
DOI: 10.1101/2023.10.09.561462

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