Article
Origins and characterization of variants shared between databases of somatic and germline human mutations.
BMC bioinformatics - 4 Jun 2020
Meyerson William, Leisman John, Navarro Fabio C P, Gerstein Mark
Abstract excerpt
BACKGROUND: Mutations arise in the human genome in two major settings: the germline and the soma. These settings involve different inheritance patterns, time scales, chromatin structures, and environmental exposures, all of which impact the resulting distribution of substitutions. Nonetheless, many of the same single nucleotide variants (SNVs) are shared between germline and somatic mutation databases, such as...
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