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Article

Germline genomic patterns are associated with cancer risk, oncogenic pathways, and clinical outcomes.

Science advances - 1 Nov 2020

Xu Xue, Zhou Yuan, Feng Xiaowen, Li Xiong, Asad Mohammad, Li Derek, Liao Bo, Li Jianqiang, Cui Qinghua, Wang Edwin

Abstract excerpt

There is an ongoing debate on the importance of genetic factors in cancer development, where gene-centered cancer predisposition seems to show that only 5 to 10% of the cancer cases are inheritable. By conducting a systematic analysis of germline genomes of 9712 cancer patients representing 22 common cancer types along with 16,670 noncancer individuals, we identified seven cancer-associated germline genomic...

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Identifiers

PMID: 33246949
DOI: 10.1126/sciadv.aba4905
PMCID: PMC7695479

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