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Metabolic Rewiring at the Pyruvate Node Drives Severe Pneumonia and T-Cell Suppression in Serotype 3 <i>Streptococcus pneumoniae</i> Infection

2026-02-15

Abstract excerpt

<h4>Background</h4> Serotype 3 (ST3) Streptococcus pneumoniae remains a major cause of invasive pneumococcal disease and pneumonia despite PCV13 introduction, in part due to potent immune evasion properties. The contribution of the pyruvate metabolic node (SpxB/LctO pathways) to ST3 pathogenesis is poorly defined. <h4>Methods</h4> We investigated oxygen-dependent fitness, virulence, and lung pathology in the S...

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Literature Corpus work
a7983d5f-0202-56bc-b062-ab4cc71f5918
DOI
10.64898/2026.02.13.705843
Open publication

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Metabolic Rewiring at the Pyruvate Node Drives Severe Pneumonia and T-Cell Suppression in Serotype 3 <i>Streptococcus pneumoniae</i> InfectionDOI 10.64898/2026.02.13.705843
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