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Article

Disease-Attenuated Pneumococcal Biosynthesis Gene Mutants Invade the Mucosal Epithelium and Induce Innate Immunity.

The Journal of infectious diseases - 15 May 2026

Weight Caroline M, Pollara Gabriele, Betts Modupeh, Ragazzini Roberta, Ramos-Sevillano Elisa, Reiné Jesús, Whelan Matthew, Afonso Guerra-Assunção José, Connor Michael, Bonfanti Paola, Jolly Clare, Noursadeghi Mahdad, Ferreira Daniela M, Brown Jeremy S, Heyderman Robert S

Abstract excerpt

BACKGROUND: Nasopharyngeal colonization by Streptococcus pneumoniae is characterized by bacterial adherence to epithelial cells, microinvasion, and innate immune activation. Previously, we have shown that two serotype 6B S pneumoniae mutant strains affecting bacterial metabolism (ΔproABC/pia and Δfhs/pia) colonize humans and mice, but in a murine disease model do not cause invasive infection. METHODS: Using an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41873613
DOI: 10.1093/infdis/jiag124
PMCID: PMC13175632

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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