Article

CHD3 and CHD4 coordinate gene expression programs to maintain β-cell function and identity in vivo

2025-11-07

Abstract excerpt

<title>Abstract</title> <p>Pancreatic β cells require tightly regulated chromatin architecture to preserve their identity and sustain glucose-stimulated insulin secretion. Here, we define cooperative and compensatory roles for the NuRD complex remodelers CHD3 and CHD4 in maintaining β-cell function. While β-cell-specific loss of CHD3 alone had little effect, combined deletion of CHD3 and CHD4 caused severe glucos...

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Literature Corpus work: a787a7e3-7b56-584f-a781-cd9133322d11
DOI: 10.21203/rs.3.rs-7880472/v1

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CHD3 and CHD4 coordinate gene expression programs to maintain β-cell function and identity in vivoDOI 10.21203/rs.3.rs-7880472/v1Read

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