Epigenetic dosage identifies two major and functionally distinct β cell subtypes

Abstract excerpt

The mechanisms that specify and stabilize cell subtypes remain poorly understood. Here, we identify two major subtypes of pancreatic β cells based on histone mark heterogeneity (β HI and β LO ). β HI cells exhibit ∼4-fold higher levels of H3K27me3, distinct chromatin organization and compaction, and a specific transcriptional pattern. β HI and β LO cells also differ in size, morphology, cytosolic and nuclear...

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