BRD4 Signaling Maintains the Differentiated State of β Cells

Abstract excerpt

In diabetes, pancreatic β cells degenerate from their mature differentiated state to a dedifferentiated state. BRD4 plays a pivotal role during embryogenesis and cancer development, but its function in modulating β-cell differentiation remains unknown. In this study, multiple models including calorie restriction db/db mouse, long-term and acute conditional knockout mouse, and human islet organoids are adopted to...

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• Genetics and Neurodevelopmental Disorders
• Pancreatic function and diabetes
• Protein Degradation and Inhibitors