Article

The Polycomb-dependent epigenome controls β-cell dysfunction, dedifferentiation and diabetes

2017-10-20

Abstract excerpt

<h4>SUMMARY</h4> Chromatin is the physical template that stabilizes and specifies transcriptional programs. To date, it remains largely unclear to what extent chromatin machinery contributes to the susceptibility and progression of complex diseases. Here, we combined deep epigenome mapping with single cell transcriptomics to mine for evidence of chromatin dysregulation in type-2 diabetes. We identify two chromati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6bd917ab-fe84-58ba-b376-abfb52a7939d
DOI: 10.1101/205641

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Polycomb-dependent epigenome controls β-cell dysfunction, dedifferentiation and diabetesDOI 10.1101/205641Read

The Polycomb-Dependent Epigenome Controls β Cell Dysfunction, Dedifferentiation, and DiabetesSemantic proximity Read

A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas.Semantic proximity Read

CHD3 and CHD4 coordinate gene expression programs to maintain β-cell function and identity in vivoSemantic proximity Read

Multiomic Profiling Identifies cis-Regulatory Networks Underlying Human Pancreatic β Cell Identity and FunctionSemantic proximity Read

Epigenetic dosage identifies two major and functionally distinct β cell subtypesSemantic proximity Read

EndoC-βH1 multi-genomic profiling defines gene regulatory programs governing human pancreatic β cell identity and functionSemantic proximity Read

Latent plasticity of the human pancreas across development, health, and diseaseSemantic proximity Read

Implications of noncoding regulatory functions in the development of insulinomasSemantic proximity Read

Epigenomic plasticity enables human pancreatic α to β cell reprogrammingSemantic proximity Read

The three-dimensional chromatin structure of the major human pancreatic cell types reveals lineage-specific regulatory architecture of T2D riskSemantic proximity Read

Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in developmentSemantic proximity Read

Chromatin accessibility differences between alpha, beta, and delta cells identifies common and cell type-specific enhancersSemantic proximity Read