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Article

Single cell transcriptomics reveal trans-differentiation of pancreatic beta cells following inactivation of the TFIID subunit Taf4.

Cell death & disease - 12 Aug 2021

Kleiber Thomas, Davidson Guillaume, Mengus Gabrielle, Martianov Igor, Davidson Irwin

Abstract excerpt

Regulation of gene expression involves a complex and dynamic dialogue between transcription factors, chromatin remodelling and modification complexes and the basal transcription machinery. To address the function of the Taf4 subunit of general transcription factor TFIID in the regulation of insulin signalling, it was inactivated in adult murine pancreatic beta cells. Taf4 inactivation impacted the expression of...

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Identifiers

PMID: 34385420
DOI: 10.1038/s41419-021-04067-y
PMCID: PMC8361202

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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