Article

Structural basis of nonmuscle myosin-2 autoinhibition mechanisms

2025-10-24

Abstract excerpt

Nonmuscle myosin-2 (NM2) is a fundamental actin-based mechanochemical ATPase that regulates cellular architecture, migration, adhesion, and force generation across diverse biological contexts. NM2 function is tightly regulated by a structural transition between an autoinhibited monomeric (10S) conformation in which ATPase activity, actin binding, and filament assembly are coordinately suppressed and an enzymatical...

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Literature Corpus work: a7815f66-c2de-5710-b608-fbf7efc19df7
DOI: 10.1101/2025.10.23.684279

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