Article

Human light meromyosin mutations linked to skeletal myopathies disrupt the coiled coil structure and myosin head sequestration

2023-05-16

Abstract excerpt

Myosin heavy chains encoded by MYH7 and MYH2 are among the most abundant proteins in human skeletal muscle. After decades of intense research using a wide range of biophysical and biological approaches, their functions have begun to be elucidated. Despite this, it remains unclear how mutations in these genes and resultant proteins disrupt myosin structure and function, inducing pathological states and skeletal m...

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Literature Corpus work: 49e67d95-d261-5c12-9f2a-df7475deeec9
DOI: 10.1101/2023.05.15.540775

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