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Article

Multiple S100 protein isoforms and C-terminal phosphorylation contribute to the paralog-selective regulation of nonmuscle myosin 2 filaments.

The Journal of biological chemistry - 21 Sept 2018

Ecsédi Péter, Billington Neil, Pálfy Gyula, Gógl Gergő, Kiss Bence, Bulyáki Éva, Bodor Andrea, Sellers James R, Nyitray László

Abstract excerpt

Nonmuscle myosin 2 (NM2) has three paralogs in mammals, NM2A, NM2B, and NM2C, which have both unique and overlapping functions in cell migration, formation of cell-cell adhesions, and cell polarity. Their assembly into homo- and heterotypic bipolar filaments in living cells is primarily regulated by phosphorylation of the N-terminally bound regulatory light chain. Here, we present evidence that the equilibrium...

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Identifiers

PMID: 30087119
DOI: 10.1074/jbc.RA118.004277
PMCID: PMC6153290

Genes

TRPM7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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