Article

Cryo-EM structure of shutdown human non-muscle myosin 2A

2025-10-15

Abstract excerpt

Determining the high-resolution structure of the widely expressed non-muscle myosin 2A (NM2A), in its dephosphorylated shutdown state, is important in understanding its regulation and disease roles. In shutdown molecules, the coiled-coil tail wraps around the myosin heads preventing them from forming filaments and binding to actin. We have solved the shutdown structure of NM2A to a global resolution of 3.0 Å in th...

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Literature Corpus work: 15f73706-9353-55fe-a127-0c9be27584f7
DOI: 10.1101/2025.10.15.682586

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