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Article

Cryo-EM structure of the inhibited (10S) form of myosin II.

Nature - 1 Dec 2020

Yang Shixin, Tiwari Prince, Lee Kyoung Hwan, Sato Osamu, Ikebe Mitsuo, Padrón Raúl, Craig Roger

Abstract excerpt

Myosin II is the motor protein that enables muscle cells to contract and nonmuscle cells to move and change shape1. The molecule has two identical heads attached to an elongated tail, and can exist in two conformations: 10S and 6S, named for their sedimentation coefficients2,3. The 6S conformation has an extended tail and assembles into polymeric filaments, which pull on actin filaments to generate force and...

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Identifiers

PMID: 33268893
DOI: 10.1038/s41586-020-3007-0
PMCID: PMC7746622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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