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Article

Effects of specific disease mutations in non-muscle myosin 2A on its structure and function.

The Journal of biological chemistry - 1 Jan 2024

Casas-Mao David, Carrington Glenn, Pujol Marta Giralt, Peckham Michelle

Abstract excerpt

Non-muscle myosin 2A (NM2A), a widely expressed class 2 myosin, is important for organizing actin filaments in cells. It cycles between a compact inactive 10S state in which its regulatory light chain (RLC) is dephosphorylated and a filamentous state in which the myosin heads interact with actin, and the RLC is phosphorylated. Over 170 missense mutations in MYH9, the gene that encodes the NM2A heavy chain, have...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38042490
DOI: 10.1016/j.jbc.2023.105514
PMCID: PMC10770755

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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