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Article

Non-muscle myosin II in disease: mechanisms and therapeutic opportunities

1 Jan 2015

Abstract excerpt

The actin motor protein non-muscle myosin II (NMII) acts as a master regulator of cell morphology, with a role in several essential cellular processes, including cell migration and post-synaptic dendritic spine plasticity in neurons. NMII also generates forces that alter biochemical signaling, by driving changes in interactions between actin-associated proteins that can ultimately regulate gene transcription. In...

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PMID: 26542704
DOI: 10.1242/dmm.022103

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