Article

Mechanistic Insights into the Active Site and Allosteric Communication Pathways in Human Nonmuscle Myosin-2C

2017-05-17

Abstract excerpt

The cyclical interaction of myosin with F-actin and nucleotides is the basis for contractility of the actin cytoskeleton. Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosins-2 isoforms. Here, we present a 2.25 Å crystal structure of the human nonmuscle myosin-2C motor domain, one of the slowest myosins characterized. In combination wi...

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Identifiers and source

Literature Corpus work: c356027f-0cf5-54af-b5e6-fda350c3f3a6
DOI: 10.1101/138891

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