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Widespread and Biologically Driven Sex Disparities in Polygenic Risk Prediction Across Complex Traits

2026-04-29

Abstract excerpt

<title>Abstract</title> <p>Polygenic risk scores (PRS) are increasingly used for disease prediction, yet their performance equity across sexes remains unclear. We evaluated sex differences in PRS performance using 3,263 scores across 145 traits from the PGS Catalog in 409,440 UK Biobank participants. Sex-differential prediction was widespread and trait-specific, affecting 15 of 64 (23%) of diseases and 43 of 81 (...

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Literature Corpus work
a7541208-9ea0-5b96-8a34-c40af6731824
DOI
10.21203/rs.3.rs-9153854/v1
Open publication

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