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The genetics of a "femaleness/maleness" score in cardiometabolic traits in the UK biobank.

Scientific reports - 5 Jun 2023

Vosberg Daniel E, Pausova Zdenka, Paus Tomáš

Abstract excerpt

We recently devised continuous "sex-scores" that sum up multiple quantitative traits, weighted by their respective sex-difference effect sizes, as an approach to estimating polyphenotypic "maleness/femaleness" within each binary sex. To identify the genetic architecture underlying these sex-scores, we conducted sex-specific genome-wide association studies (GWASs) in the UK Biobank cohort (females: n = 161,906;...

Topics

Humans
Male
Female
Genome-Wide Association Study
Biological Specimen Banks
Mental Disorders
Cardiovascular Diseases
United Kingdom
Polymorphism, Single Nucleotide

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37277458
DOI: 10.1038/s41598-023-36132-1
PMCID: PMC10241870

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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