Article

Mapping AAV capsid sequences to functions through function-guided <i>in silico</i> evolution

2024-10-11

Abstract excerpt

Artificial intelligence (AI) offers significant potential to accelerate the functional engineering of adeno-associated virus (AAV) capsids in a time- and cost-efficient manner. However, existing approaches lack the ability to systematically map capsid sequences to multifunctional properties. To address this challenge, we developed ALICE, a knowledge-driven platform for in silico AAV capsid engineering that direct...

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Literature Corpus work: a73e95c5-74a8-5964-af71-ee496f5f55fc
DOI: 10.1101/2024.10.11.617764

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