Article

Prediction of Adeno-Associated Virus Fitness with a Protein Language Based Machine Learning Model

2024-08-19

Abstract excerpt

Adeno-associated viral (AAV)-based therapeutics have the potential to transform the lives of patients by delivering one-time treatments for a variety of diseases. However, a critical challenge to their widespread adoption and distribution is the high cost of goods (CoGS). Reducing manufacturing costs by developing AAV capsids with improved yield, or fitness, is key to making gene therapies more affordable. AAV fit...

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Literature Corpus work: 347ee8f9-015d-50e6-9588-29437e540bd5
DOI: 10.1101/2024.08.19.608620

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