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Article

Steering Protein Generative Models at Test-Time for Guided AAV2 Capsid Design.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2026

Viggiano Ben, Lu Wenhui Sophia, Zhang Xiaowei, Mille-Fragoso Luis S, Gao Xiaojing J, Ashley Euan, Wong Wing Hung

Abstract excerpt

Recent advances in protein generative models have created new opportunities for protein engineering. However, a significant challenge remains in effectively steering these models to generate sequences with specific, desired functionalities, especially when these properties are defined by "black-box" or non-differentiable fitness functions. To address this, we present ProVADA+, a model-agnostic framework that...

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Identifiers

PMID: 41758159
DOI: 10.1142/9789819824755_0031
PMCID: PMC12952671

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