Article

EvoPRAISE: computationally guided directed evolution for rational AAV capsid engineering

2025-11-04

Abstract excerpt

<h4>SUMMARY</h4> Advances in neuroscience and gene therapy would be greatly accelerated by adeno-associated virus (AAV) vectors capable of crossing the blood–brain barrier (BBB). Unfortunately, capsids evolved in mice often fail to function in other species, limiting applications in non-model animals such as hibernators. To overcome this limitation, we developed Evolutionary Optimization combined with APPRAISE (E...

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Literature Corpus work: 43e44032-842e-5e8b-a332-8628710a5fbe
DOI: 10.1101/2025.11.02.686002

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