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Polygenic score analysis identifies distinct genetic risk profiles in Alzheimer’s disease comorbidities

3 Apr 2025

Abstract excerpt

Alzheimer’s disease (AD) is usually accompanied by comorbidities such as type 2 diabetes (T2D), epilepsy, major depressive disorder (MDD), and migraine headaches (MH) that can significantly affect patient management and progression. As AD, these comorbidities have their own cumulative common genetic risk component that can be explored in a single individual through polygenic scores. Utilizing data from the UK...

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PMID: 40181078
DOI: 10.1038/s41598-025-95755-8

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