Article

TLR8 escapes X chromosome inactivation in human monocytes and CD4+ T cells

2023-08-18

Abstract excerpt

<title>Abstract</title> <p><bold>Background. </bold>Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity and autoimmune pathogenesis. TLR7 and TLR8 are respectively encoded by adjacent X-linked genes. We previously established that <italic>TLR7</italic> evades X chromosome inactivation (XCI) in female immune cells. Whether <itali...

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Literature Corpus work: a72df9de-dc88-530b-b5d2-5db99af13b66
DOI: 10.21203/rs.3.rs-2495331/v1

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