Article

<i>TLR8</i>escapes X chromosome inactivation in human monocytes and CD4<sup>+</sup>T cells

2023-08-13

Abstract excerpt

Human endosomal Toll-like receptors TLR7 and TLR8 recognize self and non-self RNA ligands, and are important mediators of innate immunity and autoimmune pathogenesis. TLR7 and TLR8 are encoded by the adjacent X-linked genes, TLR7 and TLR8 . We previously established that TLR7 evades X chromosome inactivation in female immune cells, and that mononuclear blood cells express more TLR7 protein in women than in men. Us...

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Literature Corpus work: 74924027-568b-50a8-9800-57c87d880dbd
DOI: 10.1101/2023.08.08.23293823

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