Article

Filamented Light (FLight) Biofabrication of Mini-Tendon Models Show Tunable Matrix Confinement and Nuclear Morphology

2025-02-08

Abstract excerpt

One hallmark of healthy tendon tissue is the high confinement of tenocytes between tightly packed, highly aligned collagen fibers. During tendinopathy, this organization becomes dysregulated, leading to cells with round-shaped morphology and collagen fibers which exhibit crimping and misalignment. The elongated nuclei in healthy tendons are linked to matrix homeostasis through distinct mechanotransduction pathways...

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Literature Corpus work: fe57aa4e-d85a-579e-8cba-283a96d64746
DOI: 10.1101/2025.02.03.636123

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