Article

The combination of <i>EWSR1-FLI1</i> and loss of one <i>EWSR1</i> allele leads to the induction of trisomy 8

2026-05-24

Abstract excerpt

Ewing sarcoma is a pediatric cancer that develops in skeletal elements. The majority of Ewing sarcoma patients carry the aberrant EWSR1-FLI1 fusion gene. Despite trisomy 8 being an additional common aberration associated with a poor prognosis for patients, its induction mechanism remains unknown. When the EWSR1-FLI1 gene is formed, the cell loses one wildtype EWSR1 allele. To elucidate the induction mechanism of...

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Literature Corpus work: a70c542b-a7bb-5234-88b7-b1df9ad0a3ae
DOI: 10.64898/2026.05.21.726567

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