Article

Endogenous EWSR1-FLI1 degron alleles enable control of fusion oncoprotein expression in tumor cell lines and xenografts

2024-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Pediatric malignancies frequently harbor chromosomal translocations that induce expression of fusion oncoproteins. The EWSR1-FLI1 fusion oncoprotein acts as a neomorphic transcription factor and is the dominant genetic driver of Ewing’s sarcoma. Interrogation of the mechanisms by which EWSR1-FLI1 drives tumorigenesis has been limited by a lack of model systems to precisely and selectively contro...

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Literature Corpus work: 62cefb38-10bb-519b-ad84-593d2ce34189
DOI: 10.1101/2024.10.27.620498

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