Article

EWSR1 prevents the induction of aneuploidy by regulating the localization of Aurora B at inner centromere

2022-06-18

Abstract excerpt

<h4>ABSTRACT</h4> EWSR1 (Ewing sarcoma breakpoint region 1) was originally identified as a part of an aberrant EWSR1/FLI1 fusion gene in Ewing sarcoma, the second most common pediatric bone cancer. Due to formation of the EWSR1/FLI1 fusion gene in the tumor genome, the cell loses one wild type EWSR1 allele. Our previous study demonstrated that the loss of ewsr1a (homologue of human EWSR1) in zebrafish leads...

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Literature Corpus work: 6e1fa50a-a4cc-57bf-baf1-fc1768806ed8
DOI: 10.1101/2022.06.17.496636

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