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Article

Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy.

The Journal of biological chemistry - 1 Jan 2000

Park Hyewon, Kim Haeyoung, Hassebroek Victoria, Azuma Yoshiaki, Slawson Chad, Azuma Mizuki

Abstract excerpt

Ewing sarcoma is a pediatric bone cancer that expresses the chimeric protein EWSR1/FLI1. We previously demonstrated that EWSR1/FLI1 impairs the localization of Aurora B kinase to the midzone (the midline structure located between segregating chromosomes) during anaphase. While localization of Aurora B is essential for faithful cell division, it is unknown whether interference with midzone organization by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33293370
DOI: 10.1074/jbc.RA120.014328
PMCID: PMC7857440

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Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy.PMID 33293370Read ↗

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