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Oncofusion-driven <i>de novo</i> enhancer assembly promotes malignancy in Ewing sarcoma <i>via</i> aberrant expression of the stereociliary protein LOXHD1

2021-02-22

Abstract excerpt

Ewing Sarcoma (EwS) is a highly aggressive tumor of bone and soft tissues that mostly affects children and adolescents. The pathognomonic oncofusion EWSR1-ETS (EWSR1-FLI1/EWSR1-ERG) transcription factors drive EwS by orchestrating an oncogenic transcription program through de novo enhancers. Pharmacological targeting of these oncofusions has been challenged by unstructured prion-like domains and common DNA bindin...

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Literature Corpus work
45afeee4-f443-5f52-ab5b-ccf6c4141c77
DOI
10.1101/2021.02.22.432287
Open publication

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Oncofusion-driven <i>de novo</i> enhancer assembly promotes malignancy in Ewing sarcoma <i>via</i> aberrant expression of the stereociliary protein LOXHD1DOI 10.1101/2021.02.22.432287
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