Article
TGF-β switches from tumor suppressor to prometastatic factor in a model of breast cancer progression
2003-10-01
Abstract excerpt
The TGF-β signaling network plays a complex role in carcinogenesis because it has the potential to act as either a tumor suppressor or a pro-oncogenic pathway. Currently, it is not known whether TGF-β can switch from tumor suppressor to pro-oncogenic factor during the course of carcinogenic progression in a single cell lineage with a defined initiating oncogenic event or whether the specific nature of the response...
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Identifiers and source
- Literature Corpus work
- a6ffa9cf-cf80-56a6-83c2-9d8ae18002e5
- DOI
- 10.1172/jci200318899