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Article

Gain or loss of TGF-β signaling in mammary carcinoma cells can promote metastasis

15 Oct 2009

Abstract excerpt

The transforming growth factor beta (TGFbeta) is a potent regulator of tumor initiation, progression and metastasis. It has been known for many years that TGFbeta signaling in the carcinoma cell can suppress or promote tumor progression depending on the context of stimulation. While the impact of TGFbeta on the carcinoma cell is significant, it is now generally accepted that primary and metastatic carcinoma...

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PMID: 19806012
DOI: 10.4161/cc.8.20.9727

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