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TGF- : Duality of Function Between Tumor Prevention and Carcinogenesis

7 Feb 2014

Abstract excerpt

Several mechanisms underlying tumor progression have remained elusive, particularly in relation to transforming growth factor beta (TGF-β). Although TGF-β initially inhibits epithelial growth, it appears to promote the progression of advanced tumors. Defects in normal TGF-β pathways partially explain this paradox, which can lead to a cascade of downstream events that drive multiple oncogenic pathways, manifesting...

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PMID: 24511106
DOI: 10.1093/jnci/djt369

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