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Coupled Cell-Intrinsic and Microenvironmental Heterogeneity Drives Divergent Trajectories in Castration-Resistant Prostate Cancer

2026-07-17

Abstract excerpt

Castration-resistant prostate cancer emerges from coupling between cell-intrinsic heterogeneity and microenvironmental constraints. Mechanistically dissecting this coupling, rather than either factor in isolation, is the central aim of this study. To systematically study the effect of intrinsic and extrinsic spatial axes on disease trajectories, we developed an integrated multiscale framework: a cellular signaling...

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Literature Corpus work
a6fe8bb3-f9aa-5cfd-ab73-19057d8d43e8
DOI
10.64898/2026.07.16.738502
Open publication

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Coupled Cell-Intrinsic and Microenvironmental Heterogeneity Drives Divergent Trajectories in Castration-Resistant Prostate CancerDOI 10.64898/2026.07.16.738502
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