Article

Serial Spatial Transcriptomics Reveal Divergent Routes to Therapy Resistance in Metastatic Breast Cancer

2026-04-15

Abstract excerpt

<title>Abstract</title> <p>Metastatic solid tumors persist by evolving therapeutic resistance through complex, heterogeneous adaptive strategies that challenge standard precision medicine approaches. Current clinical decision making relies on bulk biomarkers, failing to resolve the spatial architecture and cellular contexts in which resistance mechanisms emerge. We present a patient-centric spatial framework, pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: de0ba0af-c6be-5d7f-8a39-073bb0203e84
DOI: 10.21203/rs.3.rs-9365657/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Serial Spatial Transcriptomics Reveal Divergent Routes to Therapy Resistance in Metastatic Breast CancerDOI 10.21203/rs.3.rs-9365657/v1Read

An Omic and Multidimensional Spatial Atlas from Serial Biopsies of an Evolving Metastatic Breast CancerSemantic proximity Read

An omic and multidimensional spatial atlas from serial biopsies of an evolving metastatic breast cancerSemantic proximity Read

Spatial Transcriptomics of TNBC tumours and corresponding lymph node metastasis reveals immune hubs driven by TNF/NF-κB signalling of TMSB4X and CD74 expressing cellsSemantic proximity Read

SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast CancerSemantic proximity Read

CancerSTFormer enables multi-scale analysis of spot-resolution spatial transcriptomes and dissects gene and immune regulatory responses to targeted therapiesSemantic proximity Read

A Pan-Cancer Single-Cell Compendium of Intratumoural HeterogeneitySemantic proximity Read

Combining spatial transcriptomics and ECM imaging in 3D for mapping cellular interactions in the tumor microenvironmentSemantic proximity Read

Single-cell RNA sequencing reveals route-specific remodeling of the tumor microenvironment and identifies predictive factors of breast cancer metastasisSemantic proximity Read

Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibitionSemantic proximity Read

Breast cancer through the lens of whole transcriptome spatial imagingSemantic proximity Read

Identification and characterization of a proliferative cell population in estrogen receptor-positive metastatic breast cancer through spatial and single-cell transcriptomicsSemantic proximity Read

Integrative analysis of scRNA-seq, spatial transcriptomics, and machine learning constructs a prognostic model for Pyrotinib resistance in breast cancerSemantic proximity Read