Article

<i>CRY2</i> missense mutations suppress P53 and enhance cell growth

2021-01-09

Abstract excerpt

Disruption of circadian rhythms increases the risk of several types of cancer. Mammalian cryptochromes (CRY1 and CRY2) are circadian transcriptional repressors that are related to DNA repair enzymes. While CRYs lack DNA repair activity, they modulate the transcriptional response to DNA damage, and CRY2 can promote SCF FBXL3 -mediated ubiquitination of c-MYC and other targets. Here, we characterize five mutations...

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Literature Corpus work: a6f1e64e-3a91-5dca-93b4-4ad1b29da6a8
DOI: 10.1101/2021.01.08.425994

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