Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cryptochrome 2 (CRY2) Suppresses Proliferation and Migration and Regulates Clock Gene Network in Osteosarcoma Cells

7 Jun 2018

Abstract excerpt

BACKGROUND Circadian disruption is a potential cancer risk factor in humans. However, the role of the clock gene, cryptochrome 2 (CRY2), in osteosarcoma (OS) is still not clear. MATERIAL AND METHODS To evaluate the potential role of CRY2 in HOS osteosarcoma cells, CRY2-silenced cell lines were established. Furthermore, we investigated the effect of CRY2 knockdown on HOS cells by CCK-8, colony formation, migration...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circadian rhythm and melatonin
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Spaceflight effects on biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29879092
DOI: 10.12659/msm.908596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cryptochrome 2 (CRY2) Suppresses Proliferation and Migration and Regulates Clock Gene Network in Osteosarcoma CellsPMID 29879092Read ↗

Period 2 Suppresses the Malignant Cellular Behaviors of Colorectal Cancer Through the Epithelial-Mesenchymal Transformation ProcessSemantic proximity Read ↗

Effect of Period 2 on the proliferation, apoptosis and migration of osteosarcoma cells, and the corresponding mechanismsSemantic proximity Read ↗

PER2 integrates circadian disruption and pituitary tumorigenesisSemantic proximity Read ↗

Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancySemantic proximity Read ↗

Major roles of the circadian clock in cancerSemantic proximity Read ↗

The core circadian gene Cryptochrome 2 influences breast cancer risk, possibly by mediating hormone signaling.Semantic proximity Read ↗

Roles of circadian clocks in cancer pathogenesis and treatmentSemantic proximity Read ↗

The role of circadian clock genes in tumorsSemantic proximity Read ↗

Loss of PERIOD2 (PER2) induces HO-1-mediated epithelial-mesenchymal transition and cisplatin resistance in Epi-A ovarian cancerSemantic proximity Read ↗

The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer developmentSemantic proximity Read ↗

Circadian rhythms and cancerSemantic proximity Read ↗

Targeting circadian transcriptional programs through a cis-regulatory mechanism in triple negative breast cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.