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Article

PER2 integrates circadian disruption and pituitary tumorigenesis

1 Jan 2023

Abstract excerpt

The role of circadian clock in pituitary tumorigenesis remains elusive. Here we investigate whether and how circadian clock modulates the development of pituitary adenomas. Methods and Results: We found altered expression of pituitary clock genes in patients with pituitary adenomas. In particular, PER2 is prominently upregulated. Further, jetlagged mice with PER2 upregulation have accelerated growth of GH3...

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PMID: 37215573
DOI: 10.7150/thno.82995

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