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Article

CRY2 missense mutations suppress P53 and enhance cell growth

28 Jun 2021

Abstract excerpt

Significance Disruption of circadian rhythms enhances cancer risk, but the underlying mechanisms are largely unknown. The circadian repressors CRY1 and CRY2 evolved from light-activated DNA-repair enzymes, suggesting that they may be involved. Here, we demonstrate that missense mutations in CRY2 reported in The Cancer Genome Atlas suppress P53 target-gene expression and enhance the growth of MYC-transformed...

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PMID: 34183418
DOI: 10.1073/pnas.2101416118

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